The Causes of Autism

The World's 1st Multi-Literature Autism Research Conglomerate


Trump’s Executive Order: Is Exiting the WHO the Right Thing to Do (for Autism)?

President Trump, Vaccines, and the WHO

Upon the start of his new administration in 2025, President Trump signed an executive order to withdraw from the World Health Organization (WHO).

“The United States noticed its withdrawal from the World Health Organization (WHO) in 2020 due to the organization’s mishandling of the COVID-19 pandemic that arose out of Wuhan, China, and other global health crises, its failure to adopt urgently needed reforms, and its inability to demonstrate independence from the inappropriate political influence of WHO member states. In addition, the WHO continues to demand unfairly onerous payments from the United States, far out of proportion with other countries’ assessed payments.  China, with a population of 1.4 billion, has 300 percent of the population of the United States, yet contributes nearly 90 percent less to the WHO.”

Mindmap Summary of Key Points

The WHO was founded in 1948, and for decades the United States of America has been a top contributor to the WHO. During the 2022-2023 biennium, the USA alone provided $1.284 billion to the WHO.

Much like criticisms of American health agencies’ failure to notify the public of discoveries this library has made at zero taxpayer cost (e.g., the FDA’s failure to notify the American public it updated the package insert for Valproate products to list ‘autism’ as a consequence since 2011), one might wonder whether a $1.284 billion dollar investment in the WHO has yielded any ROI.

An ‘investment’ is the proper term to view contributions the USA has made to the WHO over the years.

However, the returns we look for are not monetary; the ROI we’ve been expecting is American health.

Given that autism incidence rates have steadily increased since the very creation of the WHO in 1948, given that chronic illnesses in the USA has risen, given that health agencies in the USA under supposed guidance from the WHO have failed to guide American health in the proper directions, it is not inappropriate to say not only has the recent $1.284 billion dollar investment of the 2022-2024 biennium been utterly wasteful, but one may question altogether whether retroactive years of funding have truly yielded any returns.

Autism incidence rates have steadily increased, not decreased, in spite of generous contributions to the WHO by the USA.

President Trump previously attempted to exit the WHO in 2020, however, this decision was reversed by the Biden administration in 2021.

In recent public statements, President Trump apparently remains unsure whether exiting the WHO was the right decision. At a rally in Las Vegas, Nevada earlier this year in 2025, he stated “Maybe we would consider doing it again. I don’t know. Maybe we would have to clean it up a little bit.”

While many have called for withdrawal from the WHO and expect President Trump to remain firm in his decision, others ring the alarm.

Time magazine, for example, hails the WHO’s efforts in reducing illnesses through the world. A recent article by Time states, “The WHO was instrumental in coordinating the eradication of smallpox and is now working to eliminate polio.”

The prevailing consensus among those who follow mainstream media is that the eradication of various illnesses around the world came through worldwide vaccine administration and that the WHO has played an important role in this matter.

Is this a true statement though?

The WHO was established in 1948.

Measles, scarlet fever, whooping cough, diphtheria, and smallpox deaths in England and Wales had already declined to less than 20 per 100,000 by 1922 (Graph 1). In all cases, declines in mortality rates occurred prior to the introduction of vaccines and before the establishment of the WHO in 1948.

Graph 1: England and Wales mortality rates from various infectious diseases from 1838 to 1978. (Record of mortality in England and Wales for 95 years as provided by the Office of National Statistics, published 1997; Report to The Honourable Sir George Cornewall Lewis, Bart, MP, Her Majesty’s Principal Secretary of State for the Home Department, June 30, 1860, pp. a4, 205; Essay on Vaccination by Charles T. Pearce, MD, Member of the Royal College of Surgeons of England; Parliamentary Papers, the 62nd Annual Return of the Registrar General 1899 (1891–1898))

In the United states, deaths per 100,000 for measles, scarlet fever, typhoid, whooping cough, and diptheria had already declined to less than 5 deaths per 100,000 by 1936 which is twelve years before the WHO was established in 1948 (Graph 2). Once again, steep declines in mortality rates occurred prior to the introduction of various vaccines and before the WHO was established.

Do vaccines really “save lives”?
Did the World Health Organization play any role in the reduction of mortality rates of these diseases?

Graph 2: United States mortality rates from various infectious diseases from 1900 to 1965. (Vital Statistics of the United States 1937, 1938, 1943, 1944, 1949, 1960, 1967, 1976, 1987, 1992; Historical Statistics of the United States— Colonial Times to 1970 Part 1; Health, United States, 2004, US Department of Health and Human Services; Vital Records & Health Data Development Section, Michigan Department of Community Health; US Census Bureau, Statistical Abstract of the United States: 2003; Reported Cases and Deaths from Vaccine Preventable Diseases, United States, 1950–2008)

Available data from 1872 through 1922 indicates vaccines were unrelated to the decline in smallpox death rates in England and Wales.

In order to show a temporal correlation between increased smallpox vaccination rates and a decrease in mortality rates, the lines should meet and cross in opposite directions to show that as smallpox vaccine coverage rates have increased, smallpox death rates have decreased. However, the data does not; smallpox mortality rates decline in spite of a decrease in smallpox vaccine coverage rates across the 50 year time period (Graph 3).

Graph 3: England and Wales smallpox mortality rate vs. smallpox vaccine coverage rates from 1872 to 1922. (Written answer by Lord E. Percy to Parliamentary question addressed by Mr. March, MP, to the Minister to Health on July 16, 1923)

Is the WHO given too much credit for reducing mortality of various illnesses worldwide that had declined prior to the WHO’s creation?

Are vaccines provided undeserved credit for reducing mortality of various illnesses worldwide that had declined prior to their introduction?

And let us not forget people can and do get polio from vaccines.

The CDC and the WHO themselves acknowledge people can and do get polio from vaccines.

The CDC has a page dedicated to education on vaccine-derived polio, acknowledging a polio case in New York in 2022 came from a vaccine.

In a 2022 article published by the WHO, the WHO also acknowledges the spread of vaccine-derived polio in the UK, Ireland, and America.

Vaccine-derived illnesses is a taboo topic among individuals who have been spoon-fed pharmaceutical propaganda; it’s a paradox to the way we view vaccines altogether.

How is a population supposed to protect themselves from a disease such as polio when the disease can mutate from a vaccine -and this is admitted in the aforementioned WHO article- to infect others?

The WHO article states: “Vaccine-derived poliovirus is a well-documented type of poliovirus that has mutated from the strain originally contained in the oral polio vaccine (OPV). The OPV contains a live, weakened form of poliovirus. On rare occasions, when replicating in the gastrointestinal tract, OPV strains genetically change and may spread in communities that are not fully vaccinated against polio, especially in areas where there is poor hygiene, poor sanitation, or overcrowding. Further changes occur as these viruses spread from person to person. The lower the population immunity, the longer this virus survives and the more genetic changes it undergoes. In very rare instances, the vaccine-derived virus can genetically change into a form that can paralyze – this is what is known as a vaccine-derived poliovirus (VDPV). “

It is unclear how much to blame vaccines themselves may be for “outbreaks” that are blamed on unvaccinated individuals, when the real culprit could be disease mutations arising out of vaccine administration. The logical fallacy is clear in the WHO’s statements: unvaccinated individuals can get polio through a genetic alteration from the oral polio vaccine itself.

In 2023, a measles “outbreak” in Maine turned out to be vaccine-strain derived as was confirmed by official CDC documents obtained by Informed Consent Action Network due to FOIA request.

How many disease “outbreaks” have occurred through the decades as a consequence of vaccine-derivation?

How are unvaccinated individuals at fault for being infected for a mutated vaccine-derived disease that originated from a vaccine to begin with?

Vaccine-Derived Disease Mutations and Genetic Mutations from Vaccines -What is the directionality of the relationship?

If the World Health Organization acknowledges a disease can mutate from a vaccine, what are the implications in light of this library’s discovery that not a single vaccine has ever been evaluated for mutagenic or carcinogenic potential?

Not a single vaccine on the market has undergone mutagenic and carcinogenic potential safety tests.

Lack of mutagenic and carcinogenic potential safety tests means the CDC never conducted safety tests to determine if a single dose or cumulative doses of vaccines can mutate genes to increase genetic susceptibility to other diseases known to man, including cancers. The evidence is publicly available on all vaccine package inserts typically in the Non-Clinical Toxicology section that the vaccine never went through safety testing for genetic mutations or increased risk of cancers.

Given the lack of mutagenic and carcinogenic safety tests for all vaccines, how does this impact our understanding of how diseases can mutate via vaccine administration?

In other words, are vaccines mutating genes that then result in disease mutation itself? This would be an interesting area for future research…albeit, perhaps not a welcome line of research for vaccine manufactures and stakeholders.

Do vaccines really save lives?

Importantly, the World Health Organization has never requested the CDC to conduct mutagenic or carcinogenic safety tests on vaccines to improve the safety of vaccines.

Why?

Are vaccines mutating genes, and are diseases also mutating as a consequence? Does the disease mutate first, and then mutate genes?

What is the direction of that relationship?

Autism and the World Health Organization

Within the domain of autism, President Trump’s executive order to withdraw from the WHO brings to light discussion regarding the WHO’s efforts surrounding autism.

In 2023, the WHO published its most recent report on neurodevelopmental disorders: “Global report on children with developmental disabilities: from the margins to the mainstream” which addresses multiple developmental disorders, such as developmental motor coordination disorder, attention deficit hyperactivity disorder (ADHD), and autism.

Surprisingly, the WHO has not filed a comprehensive report on autism spectrum disorders alone since 2014 which leaves the world with an outdated literature review of autism.

The WHO’s 2023 report focuses on multiple neurodevelopmental disorders, not just autism.

Given increasing autism incidence rates now at 1 in 30 in America, it is heavily arguable that autism deserves a complete and isolated review of the literature and it’s own extended analysis conducted by the WHO considering the USA was one of it’s largest contributors.

Has the WHO left autism in America ignored and neglected?

Let us now review the specific documents the WHO has published on neurodevelopmental disorders to answer this question.

Surprisingly, the WHO has scarcely published any reports on neurodevelopmental disorders through the years.

Only the following documents on neurodevelopmental disorders could be identified in WHO’s archives:

On the WHO website, the most recent article on autism was published nearly two years ago November 2023.

It was surprising to see that the WHO has not published an updated literature review in their addressing of the rising autism epidemic, and the November 2023 article proudly cites the 10 year old and outdated 2014 resolution by the Secretariat. A measly 4 citations are provided in the WHO’s November 2023 article on autism and 3 of the citations focus on berating Andrew Wakefield -the Wakefield matter is outdated by 2 decades as the evidence has continued to pile up regarding vaccines and autism, yet many continue to believe this matter is the sole-basis for the autism-vaccine debate.

Nevertheless, why is the WHO on their most recent November 2023 article citing the 2014 “Comprehensive and coordinated efforts for the management of autism spectrum disorders”?

Does the WHO not intend to publish an updated review of the autism literature, which has only grown exponentially?

The WHO’s citing of the 2014 report in their November 2023 article, as well as the WHO’s board overview of developmental disabilities in their September 2023 report, is a strong sign that priority is not being given to autism spectrum disorders.

If ever there was a time for the WHO to have acted under influence of financial contributions, it would’ve been for autism considering the USA is dealing with exponentially rising autism rates and has been one of the WHO’s largest financial contributors.

But perhaps money doesn’t talk after all.

The USA’s $1.284 billion contribution to the WHO was for naught.

WHO Report: Autism spectrum disorders & other developmental disorders From raising awareness to building capacity” World Health Organization, Geneva, Switzerland 16-18 September 2013

This was the WHO’s first published report on autism and other neurodevelopmental disorders. There are several major flaws in this first report that are not corrected in subsequent reports.

Quote: “There are many possible explanations for this apparent increase in prevalence, including improved awareness, expansion of diagnostic criteria, better diagnostic tools and improved reporting. Other likely contributors comprise changes in diagnostic practices, including expansion of developmental screening, increased diagnosis and diagnostic substitution, whereby children who in the past would have been identified as having an intellectual disability are now being diagnosed with ASDs. Some of the increase in prevalence may also be the result of diagnostic accretion, whereby some people are given more than one diagnosis, and hence the prevalence appears higher, even though the same number of people is affected.”

Quote: “Developmental disorders, including ASDs, are disorders of early brain development, and although the cause of ASDs remains unknown, some specific prenatal, perinatal and environmental risk factors, such as high maternal and paternal age and specific gene mutations, have been identified. It is unclear what role these risk factors may play in the reported increase in prevalence.”

Quote: “Highlighting that there is no valid scientific evidence that childhood vaccination leads to autism spectrum disorders.”

Overall Critique: The report has zero mentions of pesticides, air pollution, valproate, or any other toxin with a scientific research paper linking it to autism risk.

Since the report was published in 2013, some of these additional literatures were still in their early stages with few publications.

However, there were published studies at the time that could have been addressed.

WHO Resolution: Comprehensive and coordinated efforts for the management of autism spectrum disorders. Sixty-Seventh World Health Assembly. A67/17. Provisional agenda item 13.4. 21 March 2014

This resolution for addressing autism spectrum disorders is cited in the WHO’s November 2023 article on autism, which is the last posting (report or otherwise) in regards to autism that the WHO has published.

The WHO Resolution for addressing autism is replete with errors.

Quote: “Characteristic features of the onset include delay in the development or temporary regression in language and social skills and repetitive stereotyped patterns of behaviour.”

Quote: “Available epidemiological data conclusively prove that there is no evidence of a causal association between measles, mumps and rubella vaccine and autism spectrum disorders. Previous studies suggesting this causal link were found to contain serious methodological flaws. There is also no evidence that any childhood vaccine increases the risk of a child developing an autism spectrum disorder. WHO has commissioned reviews of the potential association between [thimerosal] preservative and aluminium adjuvants contained in inactivated vaccines and the risk of developing autism spectrum disorders. The results firmly support the conclusion that no such association exists.”

Quote: “…to implement strategies for health promotion and prevention of life-long disabilities associated with autism spectrum disorders, by: developing and implementing multisectoral approaches for the promotion of health and psychosocial well-being of persons with autism spectrum disorders, the prevention of associated disabilities and co-morbidities…”

Quote: “The Secretariat has contributed to compiling data on autism spectrum disorders through the following projects. A global survey on resources for child mental health was conducted in 2005, and in 2011 a similar survey of child, adolescent and maternal mental health resources was undertaken in the Eastern Mediterranean Region. Their findings revealed that few resources are directed towards management of autism spectrum disorders or even mental health care in general. Moreover, the scarce resources that are available are often inefficiently used and inequitably distributed. The Mental Health Gap Action Programme’s Evidence Resource Centre contains systematic reviews of the evidence for effective interventions for prevention and management of developmental disorders including autism spectrum disorders.”

Overall Criticism: Once again, there is no mention of a ‘comprehensive and coordinated’ effort to address any toxins associated with autism. There is zero mention of environmental toxins in this resolution by the WHO Secretariat. The defense of vaccines given the WHO’s heavy funding from the vaccine industry is expected. However, by 2014, there were growing literatures on pesticides, air pollution, and valproate that were unacknowledged.

The failure to address environmental toxins is surprising, as well as the exclusion of mentioning valproate as a risk factor for autism considering the year prior in 2013 there was a publication in the prestigious journal JAMA that found prenatal valproate exposure was associated with increased risk of autism [13].

After this report in 2014, nearly a decade went by before the WHO’s next publication on neurodevelopmental disorders in 2023.

The South-East Asia region of the WHO published a report addressing autism spectrum disorder in 2017 (addressed next).

However, the WHO as an integrative whole (non-region specific) has not conducted an updated literature review and report of the autism literature, and has not updated their resolution for addressing autism spectrum disorders since this was published in 2014.

WHO Report: WHO South-East Asia Regional Strategy on Autism Spectrum Disorders. 2017

This report is classified as the South-East Asia regional strategy for addressing autism [14]. This report is a lone document amongst others: no other regional strategy reports for addressing autism could be identified.

Given increasing autism incidence rates in the USA, why hasn’t the WHO conducted a regional strategy specifically for the USA?

As with previous WHO publications on autism thus far, the report falls short on various fronts.

Major Criticisms:

Overall criticism: the report echoes previous and future WHO publications that cheerlead for autism by advocating for better support systems, leadership, and governance to manage autism. The report ironically calls for better research on autism yet fails to address the available literatures on pesticides, air pollution, and valproate associated with autism.

In regards to why the South-East Asia region obtained a regional strategy for addressing autism but not other regions and none thereafter, the evidence points toward the designation of Ms Saima Wazed as a ‘WHO Champion’ as well as a WHO International Autism Conference for the South-East Asia region in April 2017.

Ms Saima Wazed Hossain was designated WHO Champion for Autism in April 2017 due to her previous regional autism efforts in South-East Asia. She later co-authored the South-East Asia regional strategy for autism after previously earning the Excellence in Public Health Award from the WHO in 2014 for her autism efforts in Bangladesh. As of January 2024, Saima Wazed has become the WHO South-East Asia Regional Director.

Did the South-East Asia region obtain a regional strategy report due to Ms. Wazed’s previous efforts surrounding autism?

The publication of the South-East Asia regional strategy for addressing autism in November 2017 occurred a few months after the South-East Asia region of the WHO had an International Autism Conference in April of the same year [15].

A review of the summary report for the WHO South-East Asia International conference earns it the same criticisms as the regional strategy report itself: utter failure in recognizing available scientific literatures to mitigate risk of autism due to environmental exposures. None of the workshops or sessions delved into the topic of reducing toxic exposures, let alone addressing environmental factors as a risk factor.

The disregard for vaccines as a contributing factor for autism was expected from both the South-East Asia autism conference and their regional strategy report.

It was not expected that growing literatures on pesticides, air pollution, and valproate would be neglected, as this constitutes an utter failure of a scientific literature review.

A question worth considering is if the South-East Asia region perhaps earned a regional strategy report for addressing autism due to financial contributions to the WHO.

The answer would appear to be no.

The USA has been a top contributor to the WHO for decades.

In fact, a review of WHO contributions during the 2016-2017 biennium reveals that the South-East Asia WHO region actually received $34.5M in contributions that came from USA funding of the WHO.

Source: https://open.who.int/2016-17/contributors/contributor

Since 2016, the South-East Asia region of the WHO has received more than $200M in USA funding. The 2022-2023 biennium reveals the largest contribution toward the South-East Asia region of the WHO, totaling $90.6M from USA funding.

A series of follow up questions are in order?

Notwithstanding the fact that the South-East Asia regional strategy for autism fails to address relevant literatures on toxins associated with autism, perhaps it’s a good thing zero WHO funding was spent on developing a USA regional strategy for managing autism or holding a conference in the USA. It would’ve been a waste of time and money without proper attention given to environmental toxins which the conference and regional strategy report ignored.

It is odd that in spite of the South-East Asia developing a regional strategy for addressing autism since 2017, seven years later the report of the Regional Director for the South-East Asia WHO region does not mention autism at all. A small section of the report is devoted to developmental disabilities and summarizes efforts that are already becoming widespread: early identification and community/parent support.

If the South-East Asia WHO region has a regional strategy for addressing autism, why not provide the public an update seven years later in the 2024 publication of the region’s efforts?

Scientific literatures on environmental toxins have only grown in that time period.

Does the WHO not intend to address any scientific literature on toxins associated with autism?

Just what exactly are the WHO’s priorities concerning autism?

Global report on children with developmental disabilities: from the margins to the mainstream. September 15, 2023.

This is the WHO’s most recent report on developmental disabilities and is supposed to contain the most updated review of the literature to inform the world on neurodevelopmental disabilities.

Surprisingly, in spite of being the latest review of the literature, the report falls short in several key areas.

Quote: “…increases in the estimated prevalence of developmental disabilities may indicate better identification and/or be due to people with developmental conditions living longer. As such, the incidence of developmental disabilities may remain the same, but increases in detection or longevity will increase prevalence over time”

Quote: “While individual prevalence studies and peer reviewed meta-analyses provide one set of estimates of prevalence, the IHME uses data synthesis and mathematical modelling to produce GBD estimates of the prevalence of specific conditions by age group, gender and location, prevalence being defined as the total number of cases in the population (Global Health Data Exchange database).”

Global report on children with developmental disabilities: from the margins to the mainstream. Geneva: World Health Organization and the United Nations Children’s Fund (UNICEF), 2023. Licence: CC BY-NC-SA 3.0 IGO.

Quote: “Animal, human cell and epidemiological studies suggest that a wide range of environmental risks impact neurodevelopment (61–75).”

Quote: “Means to mitigate risks related to environmental health include limiting heavy metals such as cadmium, lead and mercury in the environment. Minimizing exposure to lead by, for instance, eliminating old lead paints and inhalation exposure can prevent lead poisoning and neurodevelopmental impairment in children.”

Needless to say, vaccines as a risk factor for autism remain unaddressed in the WHO 2023 report. From a standpoint of vaccine safety advocacy which calls for improvements in vaccine safety tests, the lack of saline-placebo controlled clinical trials and the lack of mutagenic and carcinogenic potential safety tests for vaccines on the market should be enough to make anyone question whether scientific studies that claim vaccines are ‘safe’ are in fact true.

Overall criticism: the most updated WHO report on developmental disabilities fails to address growing available scientific literatures on multiple environmental toxins associated with autism, and thus, cannot provide the world at large strategies for mitigating autism risk via reducing toxic exposures.

Is the WHO’s priority solely on managing autism after diagnoses?
Is there no priority given on managing autism prevention?

Before summarizing the entirety of the WHO’s efforts on autism spectrum disorders, we will now turn our attention to another matter: Valproate.

Summary and recommendations from the second joint meeting of the WHO Global Advisory Committee on Vaccine Safety (GACVS) and the WHO Advisory
Committee on Safety of Medicinal Products (ACSOMP)
14–16 December 2022

In December 2024, I announced my discovery and contribution to the Valproate-Autism literature that the FDA did not inform the public via a drug safety communication in 2011 of the addition of ‘autism’ as an adverse effect for offspring of mothers who took Depakote/Depakene products during pregnancy.

It is presently unknown how proper announcement by the FDA would have impacted autism incidence rates around the USA or world.

To this day, most Americans and countries that fund the WHO remain unaware of the valproate-autism connection.

However, it is interesting to discover that technically the World Health Organization has been warning against valproate products during pregnancy due to risk of neurodevelopmental disorders to offspring as early as 2015 via their Mental Health Gap Action Programme:

“Patients’ comorbidities and childbearing potential also have to be considered when recommending a newer antiepileptic medication in those with medication resistant convulsive epilepsy as some antiepileptic medications are associated with a higher risk of teratogenicity and worst neurodevelopmental outcomes than others (e.g., valproic acid).”

No specific mention of autism itself being the neurodevelopmental outcome in their May 2015 WHO mhGAP Guideline Update.

In January 2023, a month after the WHO’s second joint meeting on vaccine safety, they published an addendum to their Mental Health GAP guidelines reminding against the use of valproate products during pregnancy “because of the high risk of birth defects and developmental disorders in children exposed to valproic acid (sodium valproate) in the womb.”

In this January 2023 addendum, the WHO fails to mention it is specifically ‘autism’ that is the neurodevelopmental disorder that is the concern.

Considering the FDA has added ‘autism’ on the package insert for Valproate products since 2011, is the WHO’s failure to specifically state that it is ‘autism’ that is the neurodevelopmental disorder at risk justifiable?

Over 100 countries implement the WHO’s Mental Health GAP (mhGAP) guidelines which discuss valproate for the treatment of bipolar disorder within the context of mental health. In these guidelines, autism is only discussed within the context of caregiver training, management of autism in the community, and treatment options. The prevention of autism via minimizing exposure to environmental toxins associated with autism is not addressed on the WHO’s mhGAP.

On May 2, 2023 the WHO issued an official statement regarding valproate, “Valproic acid (sodium valproate) should not be prescribed to women and girls of childbearing potential because of the high risk of birth defects and developmental disorders in children exposed to valproic acid (sodium valproate) in the womb.”

For a third time, the WHO omits specifically which neurodevelopmental disorders are the ones at risk.

Later in 2023, the WHO’s November 2023 mhGAP publication echoes previous warnings: “Valproic acid (sodium valproate) is not recommended in women and girls of childbearing potential owing to the high risk of birth defects and neurodevelopmental disorders in children exposed to valproic acid (sodium valproate) in the womb.”

Now for at least a fourth time the WHO omits it is ‘autism’ that is the neurodevelopmental disorder at risk.

Why the omission?

It is worth noting that the WHO’s first mhGAP publication in 2008 does not mention valproate products at all, and therefore no comments are made on neurodevelopmental risks. Va

Given the increasing incidence rates of autism in the USA, is such an omission of ‘autism’ being the specific disorder that is at risk due to prenatal valproate exposure ethical?

A series of follow up questions are in order:

  1. Does the WHO know about the Valproate-Autism connection as noted on FDA package inserts and in the available scientific literature?
  2. If the WHO knows about the Valproate-Autism connection…
    • Are they deliberately omitting this knowledge from their statements, addendums, and guidelines to countries around the world?
    • What are the consequences for omitting ‘autism’ as this significant detail?
      • Are there legal consequences to this?
      • Are there ethical implications to this?
  3. How did the WHO first come to know about the Valproate-Autism connection?
    • Did the USA FDA inform selected officials at the WHO about the package insert for Valproate products?
    • Is the WHO versed in the Valproate-Autism literature and purposefully omitting this from their reports?
  4. In what year did the WHO first learn about the Valproate-Autism connection?
    • Have they known since 2011 when the package inserts for valproate were updated in the USA to list ‘autism’?

Given the aforementioned regarding the WHO’s omission of ‘autism’ when referring to risks of valproate products during pregnancy, can it be concluded the WHO is intentionally covering this evidence?

A Summary of the WHO’s Autism Failures

Given the World Health Organization has failed in the following areas concerning autism spectrum disorders:

this researcher concludes that President Trump’s decision to withdraw from the WHO was the correct decision.

The World Health Organization’s priorities regarding autism are not on autism prevention, but focus on creating governance, infrastructure, and workforce to manage autism. Further reliance on the WHO under the influence of poor literature reviews with almost zero strategies for mitigating risk of toxic exposures would constitute further scientific negligence toward addressing this important matter.

It is unclear at the present time why the WHO is omitting important literatures such as pesticides, air pollution, and valproate concerning neurodevelopmental disorders. Conflicts of interest that may contribute toward negligence of scientific literature, while important, are beyond the scope of this analysis, as this review has focused exclusively on evaluating the proficiency of the WHO’s literature review on environmental toxins associated with autism based upon available scientific evidence to answer the question: has the WHO conducted a thorough review of the literature to provide a well-rounded approach toward mitigating risk of autism?

The answer, in my review, is no.

Exiting the WHO, based upon their reports, yields little impact toward autism spectrum disorders and could perhaps free up resources internally within the USA toward addressing factors the WHO has neglected.

This analysis is provided with zero conflicts of interest: this library has never received funding and is independently researched by a Board Certified Behavior Analyst employed full-time in early intervention Applied Behavior Analysis services for children with autism.

References

  1. Byrd et al. (2002). Report to the Legislature on the Principal Findings from The Epidemiology of Autism in California: A Comprehensive Pilot Study. https://www.dds.ca.gov/wp-content/uploads/2019/05/DSInfo_ReportToTheLegislature_200221017.pdf
    • “The observed increase in autism cases cannot be explained by a loosening in the criteria used to make the diagnosis.
    • Some children reported by the Regional Centers with mental retardation and not autism did meet criteria for autism, but this misclassification does not appear to have changed over time.
    • Children served by the State’s Regional Centers are largely native born and there has been no major migration of children into California that would explain the increase in autism.”
  2. Hertz-Picciotto, I., & Delwiche, L. (2009). The rise in autism and the role of age at diagnosis. Epidemiology (Cambridge, Mass.), 20(1), 84–90. https://doi.org/10.1097/EDE.0b013e3181902d15
    • “In summary, the incidence of autism rose 7- to 8-fold in California from the early 1990s through the present.

      Quantitative analysis of changes in diagnostic criteria, inclusion of milder cases, and an earlier age at diagnosis suggests that these factors probably contribute 2.2-fold, 1.56-fold, and 1.12-fold increases in autism, and hence cannot fully explain the magnitude of the rise in autism.”
  3. Maenner, M. J., Rice, C. E., Arneson, C. L., Cunniff, C., Schieve, L. A., Carpenter, L. A., Van Naarden Braun, K., Kirby, R. S., Bakian, A. V., & Durkin, M. S. (2014). Potential impact of DSM-5 criteria on autism spectrum disorder prevalence estimates. JAMA psychiatry71(3), 292–300. https://doi.org/10.1001/jamapsychiatry.2013.3893
    • “Based on these findings, ASD prevalence per 1000 for 2008 would have been 10.0 (95% CI, 9.6–10.3) using DSM-5 criteria compared with the reported prevalence based on DSM-IV-TR criteria of 11.3 (95% CI, 11.0–11.7).
    • Autism spectrum disorder prevalence estimates will likely be lower under DSM-5 than under DSM-IV-TR diagnostic criteria, although this effect could be tempered by future adaptation of diagnostic practices and documentation of behaviors to fit the new criteria.”
  4. Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., Kurzius-Spencer, M., Zahorodny, W., Robinson Rosenberg, C., White, T., Durkin, M. S., Imm, P., Nikolaou, L., Yeargin-Allsopp, M., Lee, L. C., Harrington, R., Lopez, M., Fitzgerald, R. T., Hewitt, A., Pettygrove, S., … Dowling, N. F. (2018). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years – Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002), 67(6), 1-23. https://doi.org/10.15585/mmwr.ss6706a1
    • “Overall, ASD prevalence estimates based on the new DSM-5 case definition were very similar in magnitude but slightly lower than those based on the historical DSM-IV-TR case definition. Three of the 11 ADDM sites had slightly higher case counts using the DSM-5 framework compared with the DSM-IV-TR.”
    • “Implementation of the new DSM-5 case definition had little effect on the overall number of children identified with ASD for the ADDM 2014 surveillance year.”
  5. Maenner, M. J., Shaw, K. A., Baio, J., Washington, A., Patrick, M., DiRienzo, M., Christensen, D. L., Wiggins, L. D., Pettygrove, S., Andrews, J. G., Lopez, M., Hudson, A., Baroud, T., Schwenk, Y., White, T., Robinson Rosenberg, C., Lee, L.-C., Harrington, R. A., Huston, M., Hewitt, A., Esler, A., Hall-Lande, J., Poynter, J. N., Hallas-Muchow, L., Constantino, J. N., Fitzgerald, R. T., Zahorodny, W., Shenouda, J., Daniels, J. L., Warren, Z., Vehorn, A., Salinas, A., Durkin, M. S., & Dietz, P. M. (2020). Prevalence of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2016. MMWR Surveillance Summaries, 69(4), 1–12. https://doi.org/10.15585/mmwr.ss6904a1
    • “In the subset of children whose records also were reviewed using ADDM Network DSM-IV-TR ASD criteria, the DSM-IV-TR criteria classified 2% more ASD cases than DSM-5 criteria.”
  6. Shaw, K. A., Maenner, M. J., Baio, J., Washington, A., Christensen, D. L., Wiggins, L. D., Pettygrove, S., Andrews, J. G., White, T., Robinson Rosenberg, C., Constantino, J. N., Fitzgerald, R. T., Zahorodny, W., Shenouda, J., Daniels, J. L., Salinas, A., Durkin, M. S., & Dietz, P. M. (2020). Early identification of autism spectrum disorder among children aged 4 years—Early Autism and Developmental Disabilities Monitoring Network, six sites, United States, 2016. MMWR Surveillance Summaries, 69(3), 1–11. https://doi.org/10.15585/mmwr.ss6903a1
    • “Using DSM-5 criteria, prevalence of ASD was lower compared with using DSM-IV-TR criteria at one site (New Jersey) of four sites that reviewed ≥50% of records using both criteria (Table 3).

      Overall prevalence at the four sites was 16.3 per 1,000 children aged 4 years using DSM-5 criteria and 18.9 per 1,000 children aged 4 years using DSM-IV-TR (prevalence ratio: 0.9; Cohen’s kappa = 0.83).”
  7. Maenner, M. J., Graves, S. J., Peacock, G., Honein, M. A., Boyle, C. A., & Dietz, P. M. (2021). Comparison of 2 Case Definitions for Ascertaining the Prevalence of Autism Spectrum Disorder Among 8-Year-Old Children. American journal of epidemiology190(10), 2198–2207. https://doi.org/10.1093/aje/kwab106
    • “We found little difference in the overall prevalence estimates based on the previous and new ADDM Network case definitions for 2014, and a slightly lower prevalence based on the new ADDM Network case definition for 2016. In addition, we found no clear differences by sex or race/ethnicity.

      There was essentially no difference by median age at first evaluation, median age at first diagnosis, and proportion of children with intellectual disability. Both case definitions failed to identify children who had been identified only by the other method. The new case definition identified some children who were missed by the previous case definition because the child’s evaluations or records could not be obtained. Additionally, a small proportion of cases identified using only the new definition had ASD diagnoses from a community provider who evaluated the child but the ADDM Network clinicians overruled the diagnosis. Likewise, the previous case definition classified some cases by reviewing evaluations and overruling the community clinician who concluded that the child did not have ASD.”
  8. Maenner, M. J., Warren, Z., Williams, A. R., Amoakohene, E., Bakian, A. V., Bilder, D. A., Durkin, M. S., Fitzgerald, R. T., Furnier, S. M., Hughes, M. M., Ladd-Acosta, C. M., McArthur, D., Pas, E. T., Salinas, A., Vehorn, A., Williams, S., Esler, A., Grzybowski, A., Hall-Lande, J., Nguyen, R. H. N., Pierce, K., Zahorodny, W., Hudson, A., Hallas, L., Mancilla, K. C., Patrick, M., Shenouda, J., Sidwell, K., DiRienzo, M., Gutierrez, J., Spivey, M. H., Lopez, M., Pettygrove, S., Schwenk, Y. D., Washington, A., & Shaw, K. A. (2023). Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020. MMWR Surveillance Summaries, 72(2), 1–14. https://doi.org/10.15585/mmwr.ss7202a1
    • Neglected to compare DSM-4 and DSM-5 differences
  9. Hughes, M. M., Shaw, K. A., DiRienzo, M., Durkin, M. S., Esler, A., Hall-Lande, J., Wiggins, L., Zahorodny, W., Singer, A., & Maenner, M. J. (2023). The Prevalence and Characteristics of Children With Profound Autism, 15 Sites, United States, 2000-2016. Public health reports (Washington, D.C. : 1974)138(6), 971–980. https://doi.org/10.1177/00333549231163551
    • Neglected to compare DSM-4 and DSM-5 differences
  10. Hughes, M. M., Shaw, K. A., Patrick, M. E., DiRienzo, M., Bakian, A. V., Bilder, D. A., Durkin, M. S., Hudson, A., Spivey, M. H., DaWalt, L. S., Salinas, A., Schwenk, Y. D., Lopez, M., Baroud, T. M., & Maenner, M. J. (2023). Adolescents With Autism Spectrum Disorder: Diagnostic Patterns, Co-occurring Conditions, and Transition Planning. The Journal of adolescent health : official publication of the Society for Adolescent Medicine73(2), 271–278. https://doi.org/10.1016/j.jadohealth.2022.12.010
    • Neglected to compare DSM-4 and DSM-5 differences
  11. Shaw, K. A., Bilder, D. A., McArthur, D., Robinson Williams, A., Amoakohene, E., Bakian, A. V., Durkin, M. S., Fitzgerald, R. T., Furnier, S. M., Hughes, M. M., Pas, E. T., Salinas, A., Warren, Z., Williams, S., Esler, A., Grzybowski, A., Ladd-Acosta, C. M., Patrick, M., Zahorodny, W., Green, K. K., Hall-Lande, J., Lopez, M., Mancilla, K. C., Nguyen, R. H. N., Pierce, K., Schwenk, Y. D., Shenouda, J., Sidwell, K., Vehorn, A., DiRienzo, M., Gutierrez, J., Hallas, L., Hudson, A., Spivey, M. H., Pettygrove, S., Washington, A., & Maenner, M. J. (2023). Early identification of autism spectrum disorder among children aged 4 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020. MMWR Surveillance Summaries, 72(1), 1–15. https://doi.org/10.15585/mmwr.ss7201a1
    • Neglected to compare DSM-4 and DSM-5 differences
  12. Patrick, M. E., Hughes, M. M., Ali, A., Shaw, K. A., & Maenner, M. J. (2023). Social vulnerability and prevalence of Autism Spectrum Disorder, Metropolitan Atlanta Developmental Disabilities Surveillance Program (MADDSP). Annals of epidemiology83, 47–53.e1. https://doi.org/10.1016/j.annepidem.2023.04.009
    • Neglected to compare DSM-4 and DSM-5 differences
  13. Christensen, J., Grønborg, T. K., Sørensen, M. J., Schendel, D., Parner, E. T., Pedersen, L. H., & Vestergaard, M. (2013). Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA309(16), 1696–1703. https://doi.org/10.1001/jama.2013.2270
  14. World Health Organization. Regional Office for South-East Asia. (‎2017)‎. WHO South-East Asia regional strategy on autism spectrum disorders. World Health Organization. Regional Office for South-East Asia. https://iris.who.int/handle/10665/259505. License: CC BY-NC-SA 3.0 IGO
  15. World Health Organization. Regional Office for South-East Asia. (‎2017)‎. International conference on autism and neurodevelopmental disorders. World Health Organization. Regional Office for South-East Asia. https://iris.who.int/handle/10665/259504. License: CC BY-NC-SA 3.0 IGO
  16. DeStefano, F., Bhasin, T. K., Thompson, W. W., Yeargin-Allsopp, M., & Boyle, C. (2004). Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan atlanta. Pediatrics113(2), 259–266. https://doi.org/10.1542/peds.113.2.259
  17. Hooker, B.S. (2018). Reanalysis of CDC Data on Autism Incidence and Time of First MMR Vaccination. Journal of American Physicians and Surgeons, 23, 4. https://www.jpands.org/vol23no4/hooker.pdf
  18. Schultz, S. T., Klonoff-Cohen, H. S., Wingard, D. L., Akshoomoff, N. A., Macera, C. A., & Ji, M. (2008). Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: the results of a parent survey. Autism : the international journal of research and practice12(3), 293–307. https://doi.org/10.1177/1362361307089518

Shh. Quiet in the hall.